Tesamorelin

Tesamorelin is the N-terminally modified compound based on 44 amino acids sequence of human GHRH.This modified synthetic form is more potent and stable than the natural peptide. It is also more resistant to cleavage by the dipetidy aminopeptidase than human GHRH.

 It stimulates the synthesis and release of endogenous GH, with an increase in level of insulin-like growth factor . The released GH then binds with the receptors present on various body organs and regulates the body composition. This regulation is mainly because of the combination of anabolic and lipolytic mechanisms.

 However, it has been found that the main mechanisms by which Tesamorelin reduces body fat mass are lipolysis  followed by reduction in triglycerides level.